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Phlebolymphedema is a medical condition that combines both lymphatic and venous issues, leading to inflammation and swelling, primarily in the lower legs and feet. This condition is commonly overlooked but is crucial to manage appropriately. If not effectively handled, it can result in wounds, recurrent infections, and pain. This comprehensive guide aims to delve into the detailed understanding of Phlebolymphedema, its causes, symptoms, and effective treatment options.

Understanding the Lymphatic System

Before discussing Phlebolymphedema, it’s essential to understand what the lymphatic system is and how it functions. The lymphatic system is a network of vessels that carry protein-rich lymph fluid throughout the body. It’s part of the immune system and plays a vital role in defending the body against bacteria and other harmful substances.

In a healthy body, lymph fluid passes through numerous lymph nodes that filter out cellular debris, waste, and damaged cells. The lymph fluid is then processed and returned to the bloodstream. This system is not closed and lacks a centralized mechanism for circulation, unlike the cardiovascular system. Therefore, the transportation of lymph tends to be slow and erratic, relying on muscle contractions, pulsations of nearby arteries, and a series of valves in the lymphatic channels that prevent the lymph fluid from flowing backward.

What is Phlebolymphedema?

Phlebolymphedema, the most common form of lymphedema in the Western world, is a condition resulting from combined lymphatic and venous insufficiency. Chronic Venous Insufficiency (CVI) is the starting point of this condition, wherein the one-way valves in the veins of the lower legs lose their ability to close completely.

While most of the blood typically moves upwards back to the heart, some blood flows backward due to faulty valves. This backward flow, known as venous reflux, strains the vein walls, and blood plasma leaks into the interstitial space. This leakage causes swelling in the feet, ankles, and calves. As CVI progresses and becomes more severe, it leads to lymphatic overload, resulting in phlebolymphedema.

Causes of Phlebolymphedema

There are several factors that can lead to the development of Phlebolymphedema. These can range from genetics to certain types of acute trauma. Some of the most common causes include:

  • Chronic Venous Insufficiency (CVI): CVI is the leading cause of Phlebolymphedema. It occurs due to damage to the valves in your leg veins. When these valves are damaged, they struggle to circulate blood, causing blood pooling, swelling, and ulcers.
  • May-Thurner Syndrome: This is a condition caused by an artery compressing a vein, specifically the right iliac artery and the left iliac vein. Complications of May-Thurner syndrome include swelling, pain, and deep vein thrombosis.
  • Deep Vein Thrombosis (DVT): More commonly known as a blood clot, DVT is a clot that occurs in a deep vein. These clots can lead to a condition called Post-Thrombotic Syndrome (PTS), which may cause chronic pain and swelling.
  • Congestive Heart Failure: Heart failure occurs when the muscles in your heart aren’t able to pump blood efficiently. Congestive heart failure can cause phlebolymphedema due to the buildup of blood pressure on the veins, causing fluid to leak out of the veins and into the tissues.
  • Cirrhosis: Cirrhosis is scarring in the liver that results from the liver trying to repair itself after it’s damaged. Cirrhosis can cause lymphatic dysfunction that leads to various forms of lymphedema.
  • Obesity: Obesity contributes to a wide range of medical conditions, including phlebolymphedema. Obese people are at an increased risk of phlebolymphedema due to excess adipose tissue (fat) placing pressure on lymphatic nodes and vessels.
  • Trauma: Acute trauma to the veins or lymphatic system can lead to phlebolymphedema. This trauma may occur as a result of an injury or surgery.
  • Genetics: Some people are more likely to get phlebolymphedema as a result of their genetics. If you have a genetic predisposition to CVI or phlebolymphedema, it’s essential to keep an eye out for any symptoms.
  • Lifestyle factors: Leading a sedentary lifestyle, smoking, and sitting for extended periods can all increase your risk of developing phlebolymphedema.

Symptoms of Phlebolymphedema

The symptoms of phlebolymphedema can range from mild to severe. They include:

  • Pain: The swelling caused by phlebolymphedema can lead to pain. Pain typically occurs in the area where swelling has happened due to increased inflammation.
  • Venous leg ulcers: Patients with phlebolymphedema are susceptible to venous leg ulcers, which are slow-to-heal wounds caused by damaged valves in the veins.
  • Swelling: Swelling is the most common symptom of phlebolymphedema due to the buildup of lymphatic fluid and blood.
  • Trouble walking: Increased swelling from phlebolymphedema can make it difficult to walk.
  • Recurring infections: Both lymphedema and chronic venous insufficiency can make people more prone to infections.
  • Decrease in mobility: Swelling in the legs can lead to decreased mobility, with some patients being stuck in bed for most of the day.
  • Hard, thick, or discolored skin: As phlebolymphedema progresses, it may lead to changes in the color and texture of your skin.

Diagnosing Phlebolymphedema

Diagnosing phlebolymphedema is a crucial first step in getting the treatment you need to live a comfortable life and avoid complications. The diagnostic process typically begins with a basic clinical exam. Your doctor will ask you about the symptoms you’re experiencing and examine your legs to check for swelling, skin problems, and other signs of phlebolymphedema.

If a clinical exam isn’t enough, your doctor may also use imaging tests. These tests are more involved than a basic exam but offer accurate results. If you’re having trouble getting a diagnosis from your doctor, you can inquire about a lymphoscintigraphy or echo-Doppler test.

Treatment Options for Phlebolymphedema

Although there’s no cure for phlebolymphedema, treatments are available that focus on managing symptoms and preventing the progression of the condition. Below are some of the most common phlebolymphedema treatment and management methods:

  • Complete Decongestive Therapy (CDT): CDT combines various techniques, including manual lymphatic drainage, exercise, compression, and skin care, to help reduce swelling and prevent complications caused by phlebolymphedema.
  • Compression Garments: Compression garments can be worn to help reduce swelling. They should always be used under the supervision of a doctor.
  • Pneumatic Pumps: Pneumatic pumps can help reduce swelling caused by lymphedema by applying gentle pressure and guiding fluid away from swollen areas.
  • Exercise: Regular exercise encourages blood flow and helps patients manage their weight, which are important steps in treating and managing phlebolymphedema.
  • Skin Care: Taking care of your skin, including moisturizing, wearing sunscreen, and keeping your skin clean, helps prevent complications such as skin ulcers and infections.
  • Manual Lymph Drainage: Manual lymphatic drainage massages can be performed at home or by a specialist to help guide lymphatic fluid away from damaged parts of the lymphatic system.


Phlebolymphedema is a prevalent condition that requires careful management to prevent complications. By understanding the causes, symptoms, and treatment options, patients can effectively manage their condition and maintain a high quality of life. Always seek medical advice if you suspect you may have phlebolymphedema. Early detection and intervention can go a long way in managing this chronic condition.